Dr.Y.D. Sharma

Education: M.Sc. Ph.D.

Teaching and Research Experience :

Teaching: Taught M.Biotech. students at AIIMS for Molecular Biology, Molecular Microbiology, and recombinant DNA Technology courses.

Research: Molecular Biology of malaria parasites
1. Awards: Shanti Swarup Bhatnagar Prize (CSIR) in 1994 for Mol. Biol. of Malaria.
2. ICMR award (Dr. M.O.T. Iyangar Memorial Prize) in 1997 for Malaria.
3. Molecular Parasitology award from Academy of Vector Borne Diseases (2000).

Fellow Ships:
Fellow of Fellow of Indian National Science Academy (FNA)
Fellow of Indian Academy of Sciences (FASc)
Fellow of National Academy of Sciences (FNASc)

Honors:

1. Mmember, Scientific Advisory Committee of Malaria Research centre

2. Chairman, Research Advisory committee of Parasite biology of Malaria Research centre.

3. Member, Shanti Swarup Bhatnagar Prize Committee of CSIR

4. Member, Biotechnology Board of Rajasthan Govt

5. Member, Biotechnology Board of Delhi Govt.

6. Member, Recombinant Drug Advisory committee of Min. of Health

7. Member, Project Advisory Committee on Animal Sciences and Biotechnology of CSIR

8. Member, Task force of HRD programme of DBT

9. Member, International Project Advisory committee of DBT.

10. Member, Sectional Committee of Animal Sciences of INSA for election of Fellows.

11. Member, Sectional Committee of Medical Sciences of Indian Academy of Sciences, Bangalore for election of Fellows.

12. Member, Board of studies of various universities (Viz. JNU, BHU, AMU, Delhi University South Campus, Himachal Univ., Devi Ahilya Univ., Banasthali Vidyapeeth Univ., Guru Nanak Dev Univ., Jiwaji Univ., Sikkim Minipal Institute of Medical Sciences)

13. Member, course curriculum development for M.Sc Biotechnology of DBT.

14. Member, selection committees of Various Universities and Institutions for various Faculty as well as Scientits posts.

15. Chairman, Store Purchase committee of AIIMS

16. Chairman Patent cell of AIIMS

17. Chairman, regularization of Research staff of AIIMS

18. Chairman, Selection committee for Research officers and fellows for intramural funding of research projects of AIIMS

19. Chairman negotiation committee of AIIMS

20. Member of several committees of AIIMS Viz. SPC, DPC for scientists, CMET, Publicity, computerization, Recombinant DNA Biosafety

21. Editorial Board member of J.Vector & Vector Borne Diseases

22. Expert (DBT Nominee) member of Biosafety committee of UCMS, Delhi.

23. Member, committee for entrance examination for the selection of JRF of DBT.

24. Expert member for ICAR QRT committee to review 5 years plan progress of its institutions.

25. Reviewer of research papers for several international journals.

26. Reviewed large number of research grants for National and International funding agencies.

27. Member, Project Advisory committee of ICMR for Vectors & Vector borne diseases.

Publications:136 papers published

Important recent Publications:

1. Sumit Rathore, Sheena Dass, Divya Kandari, Inderjeet Kaur, Mayank Gupta, and Yagya D. Sharma. Basigin interacts with Plasmodium vivax tryptophan-rich antigen PvTRAg38 as a second erythrocyte receptor to promote parasite growth. J.Biol.Chem. 292 (2): 462-476 (2017).

2. Mohd. Shoeb Alam, Vandana Choudhary, Mohammad Zeeshan, Rupesh K.Tyagi, Sumit Rathore and Yagya D. Sharma. Interaction of Plasmodium vivax Tryptophan-Rich Antigen PvTRAg38 with Band 3 on Human Erythrocyte Surface Facilitates Parasite Growth. J.Biol. Chem. 290: 20257-20272 (2015).

3. Mohd. Shoeb Alam, Mohammad Zeeshan, Sumit Rathore, and Yagya D. Sharma. Multiple Plasmodium vivax proteins of Pv-fam-a family interact with human erythrocyte receptor Band 3 and have a role in red cell invasion. Biochem.Biophys. Res. Commn. 478: 1211-1216 (2016).

4. Mohd. Shoeb Alam, Sumit Rathore, Rupesh K.Tyagi, and Yagya D. Sharma. Host-Parasite interaction: Multiple sites in a Plasmodium vivax tryptophan-rich antigen PvTRAg38 interact with its erythrocyte receptor band 3. FEBS Letters. 590, 232-241 (2016).

5. Mohd. Shoeb Alam, Mohammad Zeeshan, Pooja Mittra, Vandana Choudhary, Yagya D. Sharma. Receptor specific binding regions of Plasmodium vivax tryptophan rich antigens and parasite growth inhibition activity of PvTRAg35.2. Microbes & Infection 18, 550-558 (2016).

6. Kriti Tyagi, Mohammad Enayet Hossain, Vandana Thakur, Pawan Malhotra, Asif Mohmmed and Yagya Dutta Sharma. Plasmodium vivax tryptophan rich antigen PvTRAg36.6 interacts with PvETRAMP and PvTRAg56.6 interacts with PvMSP7 during erythrocytic stages of the parasite. PLOS ONE 11(3) e0151065 (2016).

7. Mohammad Zeeshan, Rupesh Kumar Tyagi, Kriti Tyagi, Mohd Shoeb Alam, and Yagya Dutta Sharma. Host-Parasite Interaction: Selective Numbers of ‘Pv-fam-a’ Family Proteins of Plasmodium vivax Bind to a Restricted Number of Human Erythrocyte Receptors. J.Infect.Dis.211: 1111-1120 (2015).

8. Mohammad Zeeshan, Kriti Tyagi, Yagya D. Sharma CD4+ T cell response correlates with naturally acquired antibodies against Plasmodium vivax tryptophan-rich antigens. Infect. Immun. 83: 2018-2029 (2015).

9. Kriti Tyagi, Deepali Gupta, Ekta Saini, Shilpa Choudhary, Mohd. Shoeb Alam, Mohammad Zeeshan, Rupesh K Tyagi, Yagya D Sharma. Recognition of human erythrocyte receptors by the tryptophan-rich antigens of monkey malaria parasite Plasmodium knowlesi. PLoS One. 10(9):E0138691 (2015).

10. Mohammad Zeeshan, Hema Bora, and Yagya D Sharma. Presence of memory T cells and naturally acquired antibodies in Plasmodium vivax malaria exposed individuals against a group of tryptophan-rich antigens with conserved sequences. J Infect Dis. 207: 175-185 (2013)

11. Rupesh K. Tyagi, Manoj K Das, Shiv S. Singh and Yagya D Sharma. Human Plasmodium knowlesi infections in Andaman and Nicobar islands of India: Discordance in drug resistance associated mutations in P. falciparum and P. knowlesi genes..J.Antimicrob. Chemother. 68 (5) 1081-88 (2013).

12. Hema Bora, Rupesh K. Tyagi and Yagya D Sharma. Defining the erythrocyte binding domains of Plasmodium vivax tryptophan rich antigen 33.5. PLoS ONE 8 (4): e62829 (2013).

13. Rupesh K. Tyagi, and Yagya D Sharma. Erythrocyte binding activity displayed by a selective group of Plasmodium vivax tryptophan rich antigens is inhibited by patients’ antibodies. PLoS ONE 7(12): e50754 (2012).

14. Mohammad Zeeshan, Mohammad Tauqeer Alam, Sumiti Vinayak, Hema Bora, Rupesh K. Tyagi, Mohd. Shoeb Alam, Vandana Choudhary, Pooja Mittra, Vanshika Lumb, Praveen Kumar Bharti, Venkatachalam Udhayakumar, Neeru Singh, Vidhan Jain, Pushpendra Pal Singh, Yagya Dutta Sharma. Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine. PLoS ONE 7(8): e43430 (2012).

15. Praveen Kumar Bharti, Man Mohan Shukla2, Yagya D. Sharma and Neeru Singh. Genetic diversity in the Block 2 region of the Merozoite Surface Protein1 (MSP-1) of Plasmodium falciparum in Central India. Malaria J. 11:78116 (2012).

16. Y.D. Sharma. Molecular surveillance of drug resistant malaria in India. Curr. Sci., 102:696-703 (2012).

17. Vanshika Lumb, Rahul Madan, Manoj K Das, Vipin Rawat, Vas Dev, Wajihullah Khan, Haris Khan and Yagya D Sharma. Differential Genetic Hitchhiking Around Mutant pfcrt Alleles in Indian Plasmodium falciparum Population. J. Antimicrob. Chemother. 67:600-608 (2012).

18. Vanshika Lumb and Yagya D. Sharma. Novel K540N mutation in Plasmodium falciparum Dihydropteroate Synthetase confers a lower level of sulfadoxine resistance than K540E mutation. Antimicrob. Agents Chemother. 55:2481-2482 (2011).

19. Vanshika lumb, Manoj K. Das, Neeru Singh, Vas Dev, Wajihullah Khan and Yagya D. Sharma. Multiple Origins of Plasmodium falciparum Dihydropteroate Synthetase Mutant Alleles Associated with Sulfadoxine Resistance in India.. Antimicrob. Agents Chemother. 55: 2813-17 (2011)

20. Hema Bora, Sheena Garg, Priyankar Sen, Deepak Kumar, Punit Kaur, Rizwan Hasan Khan, and Yagya D. Sharma. Plasmodium vivax Tryptophan-Rich Antigen PvTRAg33.5 contains Alpha Helical Structure and Multidomain Architecture. PlosOne 20; 6 (1) e16294 (2011).

21. Manoj K. Das, Vanshika Lumb, Pooja Mittra, Shiv S. Singh, Aditya P. Dash and Yagya D. Sharma. High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India. J. Antimicrob. Chemother. 65:1258-1261 (2010).